Abstract Allergic reaction to liposomal amphotericin B is rare.We report a case Lead Wires of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation.We also present Rattles the results of subsequent skin prick and intradermal testing to liposomal amphotericin on the patient and three healthy controls, highlighting the need for further research into the immunopathogenesis of this reaction.